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我们对２３对“原因不明”习惯性流产夫妇的ＨＬＡ，Ａ，Ｂ，Ｃ抗原进行了分型并以３０对正常夫妇做对照。同时还研究了流产患者血浆中ＩｇＧ、ＩｇＭ、ＩｇＡ、Ｃ３、Ｃ４的变化。结果表明：①Ａ１１，Ａ２６，Ｂ１４可能与习惯性流产有关联。②流产夫妇问ＨＬＡ．Ａ，Ｂ，Ｃ抗原相容性并不增大。③两组ＨＬＡ，Ａ，Ｂ，Ｃ抗原纯合性无差异。④就单个抗原而言，流产组夫妇Ｂ５相同者明显高于对照组（Ｐ＜０．００１），其他各位点无明显差异。⑤习惯性流产患者血浆中ＩｇＧ、ＩｇＭ及补体Ｃ３、Ｃ４含量较正常对照组轻度增高，但无统计学意义，而血浆申ＩｇＡ的含量则明显升高（Ｐ＜０．００１）。我们还检测了９５例“原因不明”的习惯性流产后者血清中抗夫淋巴细胞抗体，其阳性率明显少于对照组（Ｐ＜０．００５）。
We typed HLA-A, B, C antigens in 23 pairs of habitual abortion couples with “unexplained causes” and compared them to 30 normal couples. At the same time, the changes of IgG, IgM, IgA, C3 and C4 in the plasma of abortion patients were also studied. The results showed that: ①A11, A26, B14 may be associated with habitual abortion. ② abortion couples asked HLA. A, B, C antigen compatibility does not increase. ③ There was no difference in the homogeneity of HLA, A, B and C antigens between the two groups. ④ For a single antigen, the same B5 in the abortion group was significantly higher than the control group (P <0.001), no significant difference in other sites. ⑤ The plasma levels of IgG, IgM and complement C3, C4 in patients with habitual abortion were slightly higher than those in normal control group, but there was no statistical significance, while plasma IgA levels were significantly increased (P <0.001). We also detected 95 cases of “unexplained” habitual abortion sera of anti-uv lymphocyte antibodies, the positive rate was significantly less than the control group (P <0.005).