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非类固醇抗炎药(NSAIDs)不是处方药就是非处方药而广泛使用,因此它经常与其它药物发生相互作用.如果相互作用涉及治疗指数大的药物,则药物一起使用所产生的相互作用,在临床上并不重要.一些潜伏危及生命的相互作用,往往涉及到在病情严重时所使用的治疗指数窄的药物.庆大霉素是最常使用的氨基糖甙类药物之一,但临床应用经常由于它的肾毒性而受到限制,它在体内不能被代谢,其血药浓度和半衰期取决于肾功能.由于它的治疗指数窄,主要在肾脏被排泄,所以在肾功能不全的病人中可迅速蓄积而达到中毒浓度.除了高龄、血容量过低、缺钾和缺镁是中毒的主要原因外,一些肾毒性药物的联用,是庆大霉素引起肾毒性的潜在危险因素.
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as either over-the-counter or over-the-counter drugs and therefore often interact with other drugs. If the interaction involves drugs with a high therapeutic index, then the drugs interact with each other in clinical and It is unimportant that some of the potentially life-threatening interactions often involve narrower therapeutic indices used in serious conditions Gentamicin is one of the most commonly used aminoglycosides, but clinical practice is often due to its Of nephrotoxicity is limited, it can not be metabolized in the body, its blood concentration and half-life depends on renal function because of its therapeutic index is narrow, mainly in the kidneys were excreted, so in patients with renal insufficiency can rapidly accumulate To reach the poisoning concentration.In addition to old age, hypovolemia, potassium deficiency and magnesium deficiency is the main reason for poisoning, some nephrotoxic drugs combined, gentamicin is a potential risk factor for nephrotoxicity.