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目的探讨食管癌组织中增殖细胞核抗原PCNA和癌基因蛋白C-erbB-2的表达与食管癌发展和预后的关系。方法用免疫组织化学方法检测PCNA和C-erbB-2在232例食管癌中的表达,并分析其意义。结果PCNA和C-erbB-2高表达者肿瘤分化程度低,恶性程度高,易转移。即PCNA和C-erbB-2的表达与食管癌的组织病理学分级和淋巴结转移呈正相关。结论联合检测PCNA和C-erbB-2将有助于判断食管癌的生物学行为和病人的预后。
Objective To investigate the relationship between the expression of PCNA and C-erbB-2 in esophageal cancer and the development and prognosis of esophageal cancer. Methods The expression of PCNA and C-erbB-2 in 232 esophageal carcinomas was detected by immunohistochemistry and its significance was analyzed. Results PCNA and C-erbB-2 overexpression of tumor differentiation is low, high degree of malignancy, easy to transfer. That PCNA and C-erbB-2 expression and esophageal cancer histopathological grading and lymph node metastasis was positively correlated. Conclusions The combined detection of PCNA and C-erbB-2 will help to determine the biological behavior of esophageal cancer and the prognosis of patients.