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目的 比较研究阿莫西林舒巴坦 (amoxicillinsulbactam)与阿莫西林克拉维酸钾、阿莫西林钠、头孢噻肟、氨苄西林舒巴坦 4种抗菌药物的体外抗菌活性。方法 对 12 1株临床分离菌株 (经VITEK全自动微生物分析仪重新鉴定 ) ,采用琼脂平板二倍稀释法测定最低抑菌浓度 (MIC)。结果 阿莫西林舒巴坦对革兰阳性球菌的敏感率为 90 .91% ,明显高于阿莫西林和头孢噻肟 ,而对革兰阴性杆菌中大肠埃希菌、肺炎克雷伯菌、嗜血杆菌属的敏感率分别为 82 .35 %、83.3%和 10 0 % ,与阿莫西林克拉维酸、氨苄西林舒巴坦和头孢噻肟相近 ,明显高于阿莫西林。对不动杆菌敏感率为 83.33% ,显著高于阿莫西林 ,略强于其他两种酶抑制剂复合制剂和头孢噻肟 ;阿莫西林舒巴坦对临床常见产 β -内酰胺酶菌也显示了较高的抗菌活性。 结论 阿莫西林舒巴坦是一对临床常见致病菌尤其对不动杆菌抗菌作用较强的酶抑制复合制剂 ,对产酶菌引起的感染具有较高的临床价值
Objective To compare the in vitro antibacterial activity of amoxicillin sulbactam, amoxicillin and clavulanate potassium, amoxicillin sodium, cefotaxime and ampicillin sulbactam. Methods A total of 121 strains of clinical isolates (re-identified by VITEK automatic microbiological analyzer) were used to determine the minimum inhibitory concentration (MIC) by agar plate double dilution method. Results The sensitivity of amoxicillin-sulbactam to gram-positive cocci was 90.91%, which was significantly higher than that of amoxicillin and cefotaxime. However, the susceptibility of Escherichia coli, Klebsiella pneumoniae, The sensitivity rates of Haemophilus were 82.35%, 83.3% and 100%, respectively, which were similar to those of amoxicillin clavulanic acid, ampicillin sulbactam and cefotaxime, which were significantly higher than that of amoxicillin. The sensitivity rate to Acinetobacter was 83.33%, which was significantly higher than that of amoxicillin, slightly stronger than the other two kinds of enzyme inhibitors and cefotaxime. Amoxicillin and sulbactam were also not sensitive to β - lactamases Shows higher antibacterial activity. Conclusion Amoxicillin and sulbactam are a pair of enzyme inhibiting compounds which are common to clinical pathogens, especially to Acinetobacter, and have high clinical value to infections caused by enzyme-producing bacteria