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小鼠给予雷公藤(TW)提取物雷公藤总甙(TⅡ或TG)30mg/kg/d连续1～3个月及停药3个月内逐月检查发现:雄鼠睾丸重量和形态、精子活力和计数与生育能力呈一致性改变。药物对小鼠有明确和可逆的抗生育作用,对精原细胞亦有影响。雌鼠仅表现为动情周期不规则,生殖器官形态及功能未见明显改变。三代雄性仔鼠外观及生殖器官未见明显异常。小鼠对药物的耐受性较大鼠高。
Mice were given Tripterygium wilfordii (TW) extract Tripterygium wilfordii glycosides (TII or TG) 30mg / kg / d for 1 to 3 months and withdrawal within 3 months of monthly inspection found: male rats testicular weight and morphology, sperm Vitality and counting change consistently with fertility. Drugs have clear and reversible anti-fertility effects on mice, but also affect spermatogonial cells. Female rats only showed irregular estrous cycle, no significant changes in the shape and function of genitalia. Three generations of male pups Appearance and genital organs no obvious abnormalities. Mice were more tolerant to drugs than rats.