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为探讨脑内神经细胞移植免疫排斥反应的程度和特点，以未发育成熟的人胚脑皮质细胞悬液为供体，以恒河猴为宿主，进行脑内异种异体移植实验。结果显示，移植后1～2周，恒河猴外周血中CD3、CD4、CD8T淋巴细胞数量和sIL-2R增高；移植后3～4周，血清中IgG、IgM和IgA增高，补体C3降低、C4正常。病理检查见移植组织局部以淋巴细胞为主的炎症细胞浸润，其中部分淋巴细胞呈CD3、CD4、CD8和HLA－DR+，移植物内血管内皮细胞下IgS／C3呈阳性反应，4周以后炎症细胞消退，细胞免疫和体液免疫各指标均恢复正常。本研究表明移植早期（4周内）宿主产生一定程度的急性免疫排斥反应，以细胞免疫为主，体液免疫参与作用。由于部分神经细胞仍然存活，表明宿主能够产生免疫耐受。
In order to explore the degree and characteristics of immunological rejection in nerve cell transplantation in the brain, the unripe embryonic human cortical cell suspension was used as the donor, and the rhesus monkey was used as the host for the intracranial xenograft experiment. The results showed that the number of CD3, CD4, CD8 T lymphocytes and sIL-2R in peripheral blood of Rhesus monkeys were increased 1-2 weeks after transplantation. The levels of IgG, IgM and IgA in serum increased and the level of complement C3 decreased after 3 to 4 weeks after transplantation. C4 is normal. Pathological examination showed lymphocyte-predominant inflammatory cell infiltration in the transplanted tissue. Some of the lymphocytes were positive for CD3, CD4, CD8 and HLA-DR +, and IgS / C3 in the vascular endothelial cells in the graft. After 4 weeks, inflammatory cells Subsided, the indicators of cellular immunity and humoral immunity returned to normal. This study shows that in the early stage of transplantation (within 4 weeks), the host produces a certain degree of acute immune rejection, which is mainly mediated by cellular immunity and humoral immunity. As some of the nerve cells are still alive, indicating that the host can produce immune tolerance.