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背景:老年高血压患者中慢性肾脏疾病较为常见。目的:比较冠心病(CHD)和终末期肾脏疾病(ESRD)事件的发生率;观察肾小球滤过率(GFR)是否为CHD的独立预测因素;报道在按照GFR分层的高危高血压患者中,与利尿剂(氯噻酮)对比,予钙通道阻断剂(氨氯地平)或血管紧张素转换酶抑制剂(赖诺普利)进行治疗在改善心血管疾病(CVD)结局方面的效果。设计:事后亚组分析。地点:多中心、随机、双盲、对照试验。参与者:将年龄≥55岁、具有至少1项CHD危险因素的高血压患者按照基线GFR分为三组:正常或升高组[≥90ml/
Background: Chronic kidney disease is more common in elderly hypertensive patients. PURPOSE: To compare the incidence of coronary heart disease (CHD) and end-stage renal disease (ESRD) events; to determine if glomerular filtration rate (GFR) is an independent predictor of CHD; to report whether high-risk hypertensive patients stratified according to GFR , Treatment with a diuretic (chlorthalidone), a pre-calcium channel blocker (amlodipine), or an angiotensin-converting enzyme inhibitor (lisinopril) has been shown to improve cardiovascular outcome (CVD) outcomes effect. Design: Subsequent analysis. Location: Multicenter, randomized, double-blind, controlled trial. Participants: Hypertensive patients aged 55 years or older with at least 1 CHD risk factor were divided into three groups according to baseline GFR: normal or elevated group [≥90 ml /