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目的探讨胎儿唇腭裂的尸解结果及致病相关因素。方法回顾性分析近20年唇腭裂围产儿64例的尸解结果及相关致病因素。结果单纯唇裂9例,单纯腭裂5例,唇裂合并腭裂50例,合并其它脏器畸形14例。男性38例,女性26例。母亲怀孕前12w患病(感冒、牙痛、腹泻等)有服药史者28例;父母吸烟者30例,饮酒者28例;6例母亲妊娠剧吐,8例宠物接触史,10例有放射线接触史,母亲有心脏病、肝炎、肾炎者15例;其家族中唇腭裂生产史者12例,有其它异常生产史前者10例。结论唇腭裂的病因是复杂的,围生儿唇腭裂的发生是遗传与环境因素共同作用的结果。
Objective To investigate the results of autopsy and related factors of fetal cleft lip and palate. Methods The autopsy results and related risk factors of 64 cases of perinatal children with cleft lip and palate during the past 20 years were retrospectively analyzed. Results Cleft lip in 9 cases, cleft palate in 5 cases, Cleft lip cleft palate in 50 cases, combined with other organ deformities in 14 cases. 38 males and 26 females. 28 mothers with medication history before the twins were pregnant (cold, toothache, diarrhea, etc.); 30 smokers with parents and 28 drinkers; 6 mothers with hyperemesis gravidarum, 8 pet contact history and 10 cases with radiation exposure History, mothers with heart disease, hepatitis, nephritis in 15 cases; its family cleft lip and palate in the production history of 12 cases, there are other abnormalities in the production of the former 10 cases. Conclusions The etiology of cleft lip and palate is complex. The occurrence of peri-cleft lip and palate is the result of both genetic and environmental factors.