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为了确认高血压病既存在遗传性左心肥大、也伴有遗传性血管“重塑”以及苯丙氨酸对其逆转效用，对１６～２０岁少年入选双亲均患本病（ＦＨ＋组）和无家族史的（ＦＨ－组）各２１名，前者以苯丙氨酸（１ｇ／ｄ）干预，后者以安慰剂（１ｇ／ｄ）平行对照，观察６个月前后２４小时动态血压、超声心动图、前臂静脉阻断式肢体流量和阻力改变等。发现ＦＨ＋组：①２４小时收缩压较高；②心脏、血管均存在遗传性结构异常；③苯丙氨酸干预６个月可有效逆转上述异常。提示本病的防治应从少年开始；遗传性心血管肥大可能是一项预报对本病“易感”的“遗传标记”；苯丙氨酸干预有效，为本病的防治拓开了新思路，提供了新手段
In order to confirm the existence of hypertensive patients with both hereditary left ventricular hypertrophy, but also with hereditary vascular “remodeling” and phenylalanine reversal effect on the selection of both parents of 16 to 20-year-old were both disease (FH + group) and 21 with no family history (FH group), the former with phenylalanine (1g / d) intervention, the latter with placebo (1g / d) parallel control, observed 6 months before and after ambulatory blood pressure, ultrasound Cardiogram, forearm venous occlusion limb flow and resistance changes. Found FH + group: ① 24 hours higher systolic blood pressure; ② heart, blood vessels have genetic structural abnormalities; ③ phenylalanine intervention 6 months can effectively reverse the abnormalities. Suggesting that the prevention and treatment of this disease should start juvenile; genetic cardiovascular hypertrophy may be a prediction of the disease “susceptible” to “genetic markers”; phenylalanine effective intervention for the prevention and treatment of the disease opened up new ideas, Provided a new means