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目的：调查医院2011年1月-2012年12月分离的耐甲氧西林金黄色葡萄球菌的耐药趋势，为临床治疗提供依据。方法收集送检标本中分离的耐甲氧西林金黄色葡萄球菌，按照全国临床检验规程分离，并采用美国临床实验室标准化研究所（CLSI）推荐的K-B法进行药敏试验。结果共分离出22株耐甲氧西林金黄色葡萄球菌，以痰标本分离率最高，占68.18%，其次分别是分泌物、清洁中段尿分别占：18.18%、13.64%；耐甲氧西林金黄色葡萄球菌对利奈唑烷、万古霉素的耐药率为0，对青霉素、甲氧西林的耐药率达到100%，对林可酰胺类、氨基糖甙类的耐药率也达70%、50%以上。结论对耐甲氧西林金黄色葡萄球菌进行及时鉴定与药敏分析，把握其耐药趋势，可有效指导临床合理用药。“,”OBJECTIVE To investigate the tendency of drug resistance of MRSA isolated from Jan 2006 to Dec 2010, so as to provide reliable evidence for clinical treatment. METHODS The MRSA strains isolated from the submitted specimens were col ected, the pathogens were isolated and identified according to the national clinical test procedures. The antimicrobial susceptibility testing was performed by using K-B method. RESULTS Altogether 22 MRSA strains have been isolated, 68.18% of which were derived from sputum, and the rest of the pathogens were successively derived from the secretion 18.18% and the urine 13.64%; the drug resistance rates of MRSA against linezolid and vancomycin 0%, the resistance rate to penicil in and methicil in was 100%, the resistance rate to lincosamides and aminoglycosides were higher than 50% and 70%. CONCLUSION It is effective to direct the reasonable clinical medication through identifying MRSA strains and performing the drug susceptibility testing in a timely manner as wel as grasping the tendency of drug resistance.