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目的 了解正常妊娠孕产妇血清ＩｇＧ、ＩｇＡ、ＩｇＭ 及Ｃ３ 水平。方法 采用单相免疫扩散法对２７３ 例正常孕产妇三种血清免疫球蛋白（Ｉｇ）和补体３（Ｃ３）水平进行了测定，并与２１ 例非妊娠妇女作比较。结果 正常妊娠组与非妊娠组比较，血清ＩｇＧ 水平降低明显，差异有显著性（ Ｐ＜ ０－０１） 。早、中、晚孕及产后分别下降４４－０３ ％ 、１８－４６％ 、３５－４５ ％ 和３５－７７％ 。除中孕组外，其它各组差异均有显著性（ Ｐ＜ ０－０１） ；血清ＩｇＡ 水平，早、中、晚孕与产后分别降低１６－６９％ 、３７－９４ ％ 、１７－８０ ％ 、５８－９４％ ，仅产后组差异有显著性（ Ｐ＜ ０－０１） ；血清ＩｇＭ 水平较非妊娠组升高，早、中、晚孕及产后分别上升４２－１５ ％ 、１６－６４ ％ 、２５－８２％ 和７－２７％ ，仅晚孕组差异有显著性（ Ｐ＜ ０－０５） 。血清ＩｇＭ 变化与孕产妇年龄有明显关系（ Ｐ＜ ０－０１）。血清Ｃ３ 水平随妊娠期的增加而上升，产后即明显降低（ Ｐ＜０－０５）。结论 正常孕产妇血清Ｉｇ 和Ｃ３ 均会发生改变，以适应其免疫反应和免疫调节过程。
Objective To understand the serum levels of IgG, IgA, IgM and C3 in normal pregnant women. Methods Three kinds of serum immunoglobulin (Ig) and complement 3 (C3) levels in 273 normal pregnant women were measured by single-phase immunodiffusion method and compared with 21 non-pregnant women. Results Compared with non-pregnant group, the level of serum IgG decreased significantly in normal pregnancy group (P <0-01). Early, middle and late pregnancy and postpartum decreased 44-03%, 18-46%, 35-45% and 35-77%. In addition to the pregnancy group, the other groups were significant differences (P <0-01); serum IgA levels, early, middle and late pregnancy and postpartum were reduced by 16-69%, 37-94%, 17-80% , 58-94% respectively. The difference was significant only in the postpartum group (P <0-01). The level of IgM in serum was higher than that of the non-pregnant group, and increased by 42-15%, 16-64% , 25-82% and 7-27%, respectively. There was a significant difference in only late pregnancy group (P <0-05). Serum IgM changes have significant relationship with maternal age (P <0-01). Serum C3 levels increased with the increase of pregnancy, postpartum was significantly reduced (P <0-05). Conclusion The serum levels of Ig and C3 in normal pregnant women will be changed to adapt to their immune response and immune regulation.