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奥曲肽(octreotide;:即SMZ 201-995)是一种长效生长抑素类似物。本文综述近年生长抑素及奥曲肽在胃肠道非肿瘤疾病中的应用。腹泻奥曲肽是当前治疗类癌综合征和分泌血管活性肠肽(VIP)肿瘤所致腹泻最有效的药物。在实验动物与人的研究表明,生长抑素及奥曲肽对腹泻疾病可能有效。回肠造口术后腹泻回肠造口术后持续严重的腹泻,通常见于结肠切除术时切除了末段回肠的患者。Cooper等报告5例直、结肠和回肠切除术后出现明显脂肪泻的病人,止泻药和禁食治疗均无效,用奥曲肽后,水、电解质和总排出均减少(除Cl~-外均无统计学差异),但脂肪排出显著增高;2例症状明显改善,3例大剂
Octreotide (SMZ 201-995) is a long-acting somatostatin analogue. This review summarizes the application of somatostatin and octreotide in gastrointestinal non-neoplastic diseases in recent years. Diarrhea Octreotide is currently the most effective drug for the treatment of carcinoid syndrome and diarrhea caused by the secretion of vasoactive intestinal peptide (VIP) tumors. Studies in laboratory animals and humans have shown that somatostatin and octreotide may be effective against diarrheal diseases. Post-Ileostomy Diarrhea Severe diarrhea persists after ileostomy, usually found in patients who have a resection of the distal ileum at colectomy. Cooper et al reported 5 cases of patients with obvious steatorrhea after colon, and ileum resection, antidiarrheal and fasting therapy were ineffective, with octreotide, water, electrolyte and total discharge were reduced (except for Cl ~ - no statistics Learning difference), but significantly increased fat excretion; 2 cases of symptoms improved significantly, 3 cases of large doses