论文部分内容阅读
作者等测定了47例系统性红斑狼疮(SLE)患者(男8例,女39例)血清中的雌二醇和睾酮含量。结果显示,女性患者睾酮低于对照组,雌二醇则与对照组无明显差异。男性患者雌二醇高于对照组,睾酮则差异不显著。男、女性患者的雌二醇/睾酮比值均较对照组为高。血清性激素水平与疾病严重度、抗dsDNA抗体、C_3、CIC及IgG间无明显相关关系。应用皮质激素治疗对血清性激素水平亦无显著影响。作者等认为,雌、雄激素间的不平衡对SLE的发病有关键性意义。
The authors determined the serum estradiol and testosterone levels in 47 patients with systemic lupus erythematosus (SLE) (8 males and 39 females). The results showed that female patients with testosterone lower than the control group, estradiol and the control group no significant difference. Male patients with higher than the control group of estradiol, testosterone was not significantly different. Male and female patients with estradiol / testosterone ratio were higher than the control group. Serum sex hormone levels and disease severity, anti-dsDNA antibody, C_3, CIC and IgG was no significant correlation between. Application of corticosteroid treatment of serum sex hormone levels also had no significant effect. The authors believe that the imbalance between estrogen and androgens is of critical importance for the pathogenesis of SLE.