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为观察补肾活血中药对膝ＤＯＡ的治疗作用，将４５只新西兰纯种大白兔，通过结扎左股静脉和臀下静脉及将结扎肢伸直位固定造成膝ＤＯＡ模型，对侧仅切开皮肤后缝合（假性手术）为对照侧。术后随机分为三组，Ａ组（空白对照组）：术后每天喂以普通饲料，于术后４、６、８Ｗ分批抽样进行观察；Ｂ组（试验预防组）：术后１Ｗ开始每天喂等量混有药物的混合饲料，抽样观察时间同Ｂ组；Ｃ组（试验治疗组）：术后６Ｗ开始给药，方法同Ｂ组，于术后８、１０、１２Ｗ抽样观察。观察方式：先行肉眼观察关节病变、然后处死行病检切片光镜观察。结果：术后４Ｗ，Ｂ组平均病损积分略低于Ａ组，但差距不大；６Ｗ、８Ｗ后，Ｂ组平均病损积分明显低于Ａ组；而Ｃ组，术后８、１０、１２Ｗ病损积分改变不大，但关节炎性病变明显减轻。说明补肾活血方药具有预防实验性家兔膝ＤＯＡ的作用，能减轻或延缓关节软骨退变的发生和发展，对己有明显退变的关节软骨难以修复，但可减缓其病变进一步加重。
To observe the therapeutic effect of Bushen Huoxue herbs on knee DOA, 45 New Zealand purebred white rabbits were ligated to the left femoral vein and inferior hip vein, and the knee joints were fixed in a straight position to create a knee DOA model. Suture (pseudo-surgery) was the control side. After surgery were randomly divided into three groups, A group (blank control group): postoperative daily feed to ordinary feed, at the 4th, 6th, and 8th postoperatively sampled for observation; B group (experimental prevention group): postoperative 1W Feed mixed feed with equal amount of mixed drugs every day. The sampling time was the same as that of group B. In group C (test treatment group), the administration began at 6 W after surgery. The method was the same as that of group B. Samples were taken at 8, 10, and 12 W after surgery. Observation methods: first observe the joint lesions with the naked eye, and then perform a light microscope observation of the disease. Results: After 4W, the average lesion scores in group B were slightly lower than those in group A, but the difference was not significant. After 6W and 8W, the average lesion scores in group B were significantly lower than that in group A. In group C, postoperative days 8, 10, The 12W lesion score changed little, but the arthritic lesions significantly reduced. It was demonstrated that Bushen Huoxue Recipe has the effect of preventing experimental knee DOA in rabbits, which can reduce or delay the occurrence and development of articular cartilage degeneration, and it is difficult to repair articular cartilage with obvious degeneration, but it can slow down the progression of the disease.