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自Tennant等(1935)首次观察到恢复缺血心肌血液灌注可产生心律失常后,近年来有关缺血心肌再灌注电生理学变化同心律失常发生的关系已日益引起重视。阻断冠脉后引起的心律失常一般在缺血后30分内最明显;而再灌注心律失常则在恢复血流后20秒内即可发生.减慢缺血心肌再灌注的速度可减少心律失常发生率.因此,迅速的血液再灌注可能是导致心律失常发生的重要原因之一。本文拟就缺血和再灌注后的电生理学变化特征,讨论再灌注心律失常的发生机制.
Since Tennant et al. (1935) first observed that the recovery of ischemic myocardial blood perfusion can produce arrhythmia, the relationship between electrophysiological changes in ischemic myocardium and arrhythmia has drawn more and more attention in recent years. Cardiac arrhythmias after coronary occlusion are generally most pronounced within 30 minutes of ischemia, whereas reperfusion arrhythmias occur within 20 seconds of resuming blood flow. Decreasing the rate of reperfusion of ischemic myocardium reduces the rhythm Therefore, rapid blood reperfusion may be one of the important causes of arrhythmia. This article intends to ischemic and reperfusion changes in electrophysiological characteristics of reperfusion arrhythmia to discuss the mechanism.