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目的 探讨感觉神经束膜炎(SPN)患者的临床和病理特点及雷公藤多甙治疗的疗效。方法报道1例SPN患者的临床和病理资料,并进行10年系统观察,相隔10年分别行左、右腓肠神经活检,并随访患者雷公藤多甙治疗疗效。结果 本例患者表现为急性起病,进行性全身麻痛,以肢体远端明显;病理特点:腓肠神经束膜增厚,神经纤维间大量胶原纤维沉积,轴索变性,髓鞘脱失;雷公藤多甙治疗后,临床症状好转,生活能自理,病理改变减轻。结论 本例SPN可能是一种自身免疫性疾病,雷公藤多甙治疗有效。
Objective To investigate the clinical and pathological features of patients with sensory fasciitis (SPN) and the therapeutic effect of tripterygium glycosides. Methods The clinical and pathological data of one case of SPN were reported and observed for 10 years. Left and right sural nerve biopsies were performed 10 years apart and followed up with tripterygium glycosides. Results The patients showed acute onset and progressive generalized numbness of pain with obvious distal limbs. The pathological features were thickening of the peroneal fascia, massive deposition of collagen fibers between nerve fibers, axonal degeneration and demyelination. Tripterygium glycosides after treatment, clinical symptoms improved, life can take care of themselves, reduce pathological changes. Conclusion This case of SPN may be an autoimmune disease, effective treatment of Tripterygium glycosides.