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多发性骨髓瘤在夫妇中发病者报告极少,迄今只1971年 Kyle 等有4组记载,日本尚未见过报道。近在长期大量使用农药 BHC 的夫妇中发现了几乎同时患多发性骨髓瘤的病例(其问仅相隔一月)。其临床表现和实验室检查极为相似。妻子在确诊前先表现有末梢神经炎。实验检查,治疗前骨髓中2例骨髓瘤细胞百分比(夫:妻为14.8%:13.6%,免疫球蛋白分别为6,500mg/dl 和6,400mg/d1),都相差无几,且异常球蛋白的类型均为 IgG(k)型,亚型亦属 IgG-I 型。
Multiple myeloma incidence in the couple reported very few, so far only 1971 Kyle, etc. There are 4 records, Japan has not seen the report. Nearly in the long-term use of pesticides BHC couple found at almost the same time multiple myeloma cases (which asked only one month apart). Its clinical manifestations and laboratory tests are very similar. Wife showed peripheral neuritis before diagnosis. The percentage of myeloma cells in the bone marrow of two cases before treatment (FH: 14.8%: 13.6% for wives, 6,500 mg / dl for immunoglobulins and 6,400 mg / dl for immunoglobulins, respectively), and the type of dystrophin Are IgG (k) type, subtype is IgG-I type.