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心室颤动-除颤时可发生一过性高血压,作者设想钙通道阻滞剂尼索地平的功能性抗肾上腺素作用可能削弱这一“肾上腺素能超射”、具有降低心肌耗氧的潜在益处。然而其它钙通道阻滞剂有降低除颤成功率的不良作用。本研究目的是评估尼索地平对心室颤动-除颤时血液动力学反应及对除颤所需能量的影响。给16只狗推注尼索地平1μg/kg,随后静滴0.075～0.5μg/kg/min,使平均血压降低,比基础水平低10～20％。电诱发室颤,然后分别用30、50和100焦耳能量电击以判
Ventricular Fibrillation - A transient hypertension occurs during defibrillation. The authors hypothesized that the functional anti-adrenergic effect of calcium channel blocker nisoldipine might weaken this “adrenergic” and reduce the potential for myocardial oxygen consumption benefit. However, other calcium channel blockers have the adverse effect of reducing the success rate of defibrillation. The purpose of this study was to evaluate the effect of nisoldipine on hemodynamic response to ventricular fibrillation-defibrillation and the energy required for defibrillation. Nigodipine 1 μg / kg was given to 16 dogs, followed by intravenous infusion of 0.075-0.5 μg / kg / min, resulting in a decrease in mean blood pressure of 10-20% below basal level. Induced ventricular fibrillation, and then with 30, 50 and 100 joules of energy shock to sentence