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目的评估尿素联合普萘洛尔治疗婴幼儿血管瘤的临床疗效观察及安全性。方法依据不同治疗方法将130例血管瘤婴幼儿分为3组,A组42例口服普萘洛尔,B组40例局部注射尿素,C组48例联合应用尿素和普萘洛尔。比较3组对不同面积及浸润深度血管瘤的治疗效果。结果 A组治愈20例(47.6%),B组治愈22例(55.0%),C组治愈38例(79.2%),C组治愈率高于A,B组(P<0.05);C组对不同面积及浸润深度血管瘤的治疗效果均优于A,B组(P<0.05)。口服普萘洛尔对治疗不同面积及浸润深度类型疗效差异无统计学意义(P>0.05)。局部注射尿素对小面积、表浅型有较好疗效。结论普萘洛尔联合尿素治疗不同面积和浸润深度血管瘤,均可获得良好效果,局部注射尿素适用浸润深度较浅的小面积血管瘤。
Objective To evaluate the clinical efficacy and safety of urea combined with propranolol in the treatment of infantile hemangiomas. Methods According to different treatment methods, 130 cases of hemangiomas were divided into 3 groups. Group A received propranolol orally. Forty cases in group B received local injection of urea, and group C received 48 cases combined with urea and propranolol. Three groups of different depth of invasion and treatment of hemangiomas. Results In group A, 20 cases were cured (47.6%), 22 cases (55.0%) were cured in group B, 38 cases (79.2%) were cured in group C, and the cure rate in group C was higher than that in group A and B (P <0.05) The treatment effect of hemangiomas with different area and depth of invasion were better than those of A and B groups (P <0.05). Oral propranolol treatment of different sizes and depth of invasion of the type of effect was no significant difference (P> 0.05). Local injection of urea on a small area, superficial type has a good effect. Conclusion Propranolol combined with urea treatment of hemangiomas of different area and depth of invasion, can get good results, local injection of urea for shallow depth of invasion of small hemangiomas.