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目的 研究人脐带血树突状细胞(DC)对LAK细胞杀伤活性的影响。方法 从人脐带血中分离出DC,以不同浓度与LAK细胞共育,检测其杀伤活性变化。结果 加入低于1×10~5/mlDC的LAK杀伤活性显著增强,高于此浓度则对LAK活性呈不显著或负面影响。结论 该结果提示脐血DC对LAK细胞杀伤活性可能具双向调节作用。
Objective To study the effect of human cord blood dendritic cells (DC) on killing activity of LAK cells. Methods DCs were isolated from human umbilical cord blood and co-cultured with LAK cells at different concentrations to detect changes in killing activity. Results The killing activity of LAK added to DCs below 1×10~5/ml was significantly increased. Above this concentration, LAK activity was not significantly or negatively affected. Conclusion This result suggests that the umbilical cord blood DCs may have a two-way regulating effect on LAK cell killing activity.