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Background Olfactory neuroblastoma(ONB)is a rare tumor that often arise from the nasal cavity.The aim of this studywas to investigate the clinical characteristics and treatments of intracranial invasive ONB.Methods Between July 2001 and August 2005,5 patients with intracranial invasive ONB were treated in ourdepartment.Their clinical features,radiological and pathological characteristics,and surgical treatments were analyzed.Among the 5 patients,1 received transnasal biopsy,and 4 were operated through the transfrontal or extended bifrontalapproaches to reconstruct the skull base.After the operation,all the patients received radiotherapy,and one receivedchemotherapy.They were followed up for 6 to 45 months.Results The ONB was resected totally in the 4 patients.In all the patients,nasal obstruction was alleviated withoutcerebrospinal fluid leakage.The visual acuity was improved in 3 patients,who had a decreased visual acuity before theoperation.Two patients had metastasis into the lumbosacral spinal canal 6 and 8 months after the operation,one of themreceived a second operation and the other died.Conclusion ONB has no specific symptoms.Intracranial ONB should be resected as far as possible,and treated byradiotherapy after the operation.
Background Olfactory neuroblastoma (ONB) is a rare tumor that often arise from the nasal cavity. The aim of this study was to investigate the clinical characteristics and treatments of intracranial invasive ONB.Methods Between July 2001 and August 2005,5,5 patients with intracranial invasive ONB were treated in our department. Their clinical features, radiological and pathological characteristics, and surgical treatments were analyzed. Among the 5 patients, 1 received transnasal biopsy, and 4 were operated through the transfrontal or extended bifrontalapproaches to reconstruct the skull base. After the operation, all the patients received radiotherapy, and one received chemotherapy for the same were up for 6 to 45 months. Results The ONB was resected completely in the 4 patients. In all the patients, nasal obstruction was alleviated without cerebrospinal fluid leakage. The visual acuity was improved in 3 patients, who had a decreased visual acuity before theoperation.Two patients had metastasis into the lumbos acral spinal canal 6 and 8 months after the operation, one of themreceived a second operation and the other died. Conlusion ONB has no specific symptoms. Intracranial ONB should be resected as far as possible, and treated byradiotherapy after the operation.