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急性心肌梗塞(AMI)的预后基本取决于病人正常和坏死心肌量的比例。Braunwald(1976年)提出用缩小梗塞范围和保存心功能的疗法可能减低病死率和病残率。其根据在于实验研究显示:(1)AMI是一个“动态过程”,心肌约在开始缺血6小时后才完全坏死;(2)减少心肌氧需、增加氧和营养的供应、使
The prognosis of acute myocardial infarction (AMI) depends basically on the proportion of normal and necrotic myocardium in the patient. Braunwald (1976) suggests that therapies that reduce infarct size and preserve heart function may reduce mortality and morbidity. The rationale is that experimental studies have shown that (1) AMI is a “dynamic process” and myocardial necrosis does not occur completely until about 6 hours after onset of ischemia; (2) myocardial oxygen demand is reduced and oxygen and nutrient supply are increased