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合成孕激素用于预防自然流产、治疗黄体缺陷所致的不育、闭经的研究和闭经治疗中雌激素状态的评价,近来在体外受精中也使用孕激素控制周期,使在胚胎移植入子宫前达到黄体早期阶段或对原发性卵巢无功能者移植卵子后以合成孕激素来支持受精卵发育。各种途径给予孕酮后有不同的血浓度;口服后血中仅出现一个短暂的峰值,皮下缓释型植入剂难以使孕激素水平达到有效浓度,即使使用大剂量孕酮可达到有效浓度,但其给药方法也是不方便的。肌注孕酮油剂能有效地吸收,半衰期为12～24小时,阴道和直肠给药根据剂量和栓剂的基质不同半衰期为6～12小时。本研究报告了滤泡期和黄体期
The synthesis of progestins for the prevention of spontaneous abortion, the treatment of infertility caused by luteal defects, amenorrhea and amenorrhea in the evaluation of estrogen status, and recently in vitro fertilization also use progesterone control cycle, so that before the embryo transfer into the uterus To achieve the early stage of corpus luteum or primary ovarian non-functional transplanted eggs after the synthesis of progesterone to support fertilized egg development. After administration of progesterone in a variety of ways have different blood concentrations; only a brief peak of blood occurs after oral administration, subcutaneous slow-release implants difficult to achieve effective levels of progesterone levels, even with high doses of progesterone can reach an effective concentration , But its administration method is also inconvenient. Intramuscular injection of progesterone oil can be effectively absorbed, half-life of 12 to 24 hours, vaginal and rectal administration according to the dose and suppository matrix different half-life of 6 to 12 hours. This study reports follicular phase and luteal phase