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目的:观察香菇多糖注射液对中晚期肺癌患者化疗后疗效及生存质量的影响。方法:将86例中晚期肺癌患者,随机分为治疗组和对照组。两组均给予多西他赛和顺铂化学治疗,治疗组在此基础上,静脉滴注香菇多糖注射液,连续治疗两个月后,分析比较2组患者实体瘤体积变化情况及临床疗效,并监测患者免疫指标和药物的毒副作用。结果:治疗后,治疗组总有效率为37.2%,高于对照组的16.3%(P<0.05);治疗组治疗后Kamofsky生活质量评分高于对照组(P<0.05);治疗组治疗后CD8+低于治疗前(P<0.05),治疗后CD4+/CD8+高于治疗前(P<0.05)。对照组治疗后CD8+、CD4+/CD8+低于治疗前(P<0.05),治疗后比较,治疗组CD3+、CD4+和CD4+/CD8+均高于对照组(P<0.05)。治疗组胃肠道反应、骨髓抑制和肝/肾功能不全的发生率均低于对照组(P<0.05)。结论:香菇多糖注射液治疗中晚期肺疗效显著,具有保护免疫功能和降低毒副作用,提高患者的生存质量。
Objective: To observe the effect of lentinan on the curative effect and quality of life of patients with advanced lung cancer after chemotherapy. Methods: 86 patients with advanced lung cancer were randomly divided into treatment group and control group. Both groups were given docetaxel and cisplatin chemotherapy, the treatment group on this basis, intravenous drip of lentinan injection, continuous treatment for two months after the analysis of two groups of patients with solid tumor volume changes and clinical efficacy, And monitoring of patient immune indicators and drug side effects. Results: After treatment, the total effective rate of the treatment group was 37.2%, higher than that of the control group (16.3%, P <0.05); the Kamofsky quality of life score of the treatment group was higher than that of the control group (P <0.05) Lower than before treatment (P <0.05), after treatment CD4 + / CD8 + than before treatment (P <0.05). The levels of CD8 + and CD4 + / CD8 + in the control group were lower than those before treatment (P <0.05). After treatment, the levels of CD3 +, CD4 + and CD4 + / CD8 + in the treatment group were significantly higher than those in the control group (P <0.05). The incidence of gastrointestinal reactions, bone marrow suppression and liver / renal insufficiency in the treatment group were lower than those in the control group (P <0.05). Conclusion: Lentinan injection is effective in treating advanced lung disease, which has the functions of protecting immune function, reducing the side effects and improving the quality of life of patients.