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目的探讨缬沙坦对兔动脉粥样硬化管壁及相关基因的研究。方法将白兔随机分成对照组.胆固醇组和不同剂量缬沙坦加胆固醇组。建立家兔动脉粥样硬化模型,观察各组家兔 c-myc、c-fos 变化及大动脉管壁、管腔和粥样斑变化。结果 (1)病理学上,高剂量组的主动脉斑块面积比明显降低(P<0.05).低剂量组与胆固醇组比较差异无统计学意义。(2)胆固醇组的动脉粥样硬化相关基因 c-mys、c-fos mRNA 表达的阳性率较对照组显著增高,而高剂量组的阳性率则显著低于胆固醇组(P<0.05),中、低剂量组与胆固醇组比较差异无统计学意义。结论大剂量的缬沙坦能有效防止兔动脉粥样硬化形成和发展。
Objective To investigate the effects of valsartan on atherosclerosis in rabbits and related genes. Methods Rabbits were randomly divided into control group, cholesterol group and valsartan plus cholesterol group. A rabbit model of atherosclerosis was established. The changes of c-myc, c-fos and the changes of aortic wall, lumen and atherosclerotic plaque in rabbits in each group were observed. Results (1) The areas of aortic plaque in the pathological and high-dose groups were significantly decreased (P <0.05), but there was no significant difference between the low-dose group and the cholesterol group. (2) The positive rate of c-myc and c-fos mRNA expression in cholesterol group was significantly higher than that in control group, while the positive rate in high-dose group was significantly lower than that in cholesterol group (P <0.05) There was no significant difference between the low-dose group and the cholesterol group. Conclusion High-dose valsartan can effectively prevent the formation and development of atherosclerosis in rabbits.