Selective monotetrahydropyranylation of symmetrical diols using P_20_5/Si0_2 under solvent-free cond

• 作 者: Hossein Eshghi Mohammad Rahimizadeh Sattar Saberi
• 机 构: Department of Chemistry,Ferdowsi University of Mashhad,Mashhad 91775-1436,Iran,
• 出 处: Chinese Chemical Letters
• 发表日期: 2008年09期
• 关键词: symmetrical methanol economically catalyzed cheap hydroxyl selectivity simply hy

Selective protection of one of the hydroxyl group in 1,n-symmetrical diols is achieved by P_2O_2/SiO_2-catalyzed reaction of the diol with dihydropyran under solvent-free conditions at room temperature.This selective protection is simple and it occurred under economically cheap conditions in high yield.The deprotected diol is simply obtained by refluxing of this compound in methanol using the same catalyst without any byproduct formation or additional purifications.

Selective protection of one of the hydroxyl groups in 1, n-symmetrical diols is achieved by P 2 O 2 / SiO 2-catalyzed reaction of the diol with dihydropyran under solvent-free conditions at room temperature. This selective protection is simple and it occurs under economically cheap conditions in high yield. The deprotected diol is simply obtained by refluxing of this compound in methanol using the same catalyst without any byproduct formation or additional purifications.