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目的:观察应用免疫增强型肠内营养制剂对胃癌术后病人辅助化疗中的临床疗效。方法:将84例胃癌术后辅助化疗病人随机分为A、B两组,每组42例。两组病人均于术中放置空肠穿刺造口管,并延期留置空肠造口管直至化疗6个疗程结束。A组每个化疗疗程经空肠造口管给予免疫增强型肠内营养液瑞能,每天1 500ml,共7 d;B组则每个化疗疗程经空肠穿刺造口管给予普通匀浆膳食,每天1 500 ml,共7 d。比较两组病人化疗后营养和免疫指标。结果:化疗后A组血红蛋白、血清清蛋白、前清蛋白及IL-2、NK细胞活性、CD3+、CD4+、CD4+/CD8+水平显著高于B组(P<0.05)。结论:在胃癌病人术后辅助化疗期间,应用免疫增强型肠内营养制剂能减少化疗药物对病人营养状况和免疫功能的影响。
Objective: To observe the clinical efficacy of adjuvant chemotherapy with adjuvant immunoenhancement in postoperative patients with gastric cancer. Methods: 84 patients with postoperative adjuvant chemotherapy for gastric cancer were randomly divided into A and B groups, 42 cases in each group. Two groups of patients were placed jejunum during operation ostomy tube, and delayed debridement of jejunostomy tube until the end of 6 courses of chemotherapy. A group of each course of chemotherapy by jejunostomy tube to give immunosuppressive enteral nutrition solution can, daily 1500ml, a total of 7 d; B group is each chemotherapy course by jejunal puncture stoma tube to give ordinary homogenate diet, daily 1 500 ml for 7 days. The two groups of patients after chemotherapy and immune indicators. Results: After chemotherapy, the levels of hemoglobin, serum albumin, prealbumin, IL-2, NK cell activity, CD3 +, CD4 + and CD4 + / CD8 + in group A were significantly higher than those in group B (P <0.05). Conclusion: The application of immune-enhancing enteral nutrition can reduce the influence of chemotherapy drugs on nutritional status and immune function in patients with gastric cancer after adjuvant chemotherapy.