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探讨血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）和神经肽（ＮＰＹ）与老年人动脉硬化之间的关系，提高动脉硬化的预防和治疗效果。方法用放射免疫法对３０例５５岁以上老人进行血浆ＥＴ、ＣＧＲＰ和ＮＰＹ的测定，并与５０例健康青年人做对照。结果老年组ＥＴ升高，ＣＧＲＰ、ＮＰＹ降低（Ｐ＜０．０５～０．０１）。结论ＥＴ升高，ＣＧＲＰ、ＮＰＹ降低表明老年人心血管分泌及调节功能失调，提示该改变可能与老年人心脑血管疾病的发生有关。
To investigate the relationship between plasma endothelin (ET), calcitonin gene related peptide (CGRP) and neuropeptide (NPY) and arteriosclerosis in the elderly to improve the prevention and treatment of atherosclerosis. Methods The plasma levels of ET, CGRP and NPY in 30 elderly people over 55 were measured by radioimmunoassay and compared with 50 healthy young people. Results In elderly group, ET increased, while CGRP and NPY decreased (P <0.05 ~ 0.01). Conclusions The increase of ET, the decrease of CGRP and NPY indicate the cardiovascular dysfunction in elderly patients, suggesting that the change may be related to the occurrence of cardiovascular and cerebrovascular diseases in the elderly.