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采用流式细胞免疫荧光技术对50例正常晚孕妇女及74例任高征患者产前、产后6小时、72小时血小板膜结合纤维蛋白原含量(Fibrinogen,Fg)进行动态观察。结果发现:产前妊高征患者血小板膜结合Fg明显高于正常晚孕妇女,且轻、中、重度妊高征患者血小板膜结合Fg含量呈递增趋势。产后6小时,妊高征组及正常晚孕组血小板膜结合Fg均明显增加。产后72小时两组均降至产前正常晚孕组水平。提示:血小板聚集性增强在妊高征发病过程中起重要作用,血小板膜结合Fg可作为监测病情的一个客观指标。
Flow cytometric immunofluorescence was used to observe the contents of fibrinogen and fibrinogen (Fg) in 50 normal pregnant women and 74 patients with hyperfunction after prenatal, 6 hours and 72 hours postpartum. The results showed that platelet membrane-bound Fg in patients with prenatal pregnancy-induced hypertension was significantly higher than that of normal pregnant women, and the platelet membrane-bound Fg content of patients with mild, moderate and severe pregnancy-induced hypertension showed an increasing trend. Postpartum 6 hours, PIH group and normal late pregnancy group platelet membrane Fg were significantly increased. 72 hours postpartum, both groups were reduced to prenatal normal late pregnancy group level. Tip: Increased platelet aggregation plays an important role in the pathogenesis of PIH. Platelet membrane Fg can be used as an objective indicator to monitor the disease.