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新华社报道,德国研究人员最新研究发现,一种细菌毒素可致细胞内的一种蛋白失活,致使细胞“自杀”。这一发现或有助于研究杀死癌细胞。德国弗赖堡大学日前发表新闻公报说,该校研究人员发现,可导致气性坏疽的产气荚膜梭菌可产生一种名为“TpeL”的梭菌毒素,这种毒素可将糖分子附着在宿主细胞的Ras蛋白上,以干扰这种蛋白的自然功能。弗赖堡大学药理学家克劳斯·阿克托里斯介绍,人类细胞中的Ras蛋白在激发细胞生长时发挥重要作用,而TpeL毒素则
Xinhua News Agency reported that the latest German researchers found that a bacterial toxin can cause a protein in the cell inactivation, resulting in cells “suicide ”. This finding may help to study the killing of cancer cells. The University of Freiburg in Germany recently published a press communiqué that researchers at the school found that Clostridium perfringens, which causes gas gangrene, produces a Clostridial toxin called “TpeL” Sugar molecules attach to the host cell’s Ras protein to interfere with the natural function of this protein. Klaus Aktoris, a pharmacologist at the University of Freiburg, described that Ras proteins in human cells play an important role in stimulating cell growth, whereas TpeL toxin