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目的分析三阴性乳腺癌(TNBC)患者的临床病理特征与预后的相关性。方法回顾性分析雌激素受体、孕激素受体和人类表皮生长因子受体2表达均为阴性的TNBC患者48例的临床病理特征,分析临床病理特征对患者5年生存预后的影响。结果 48例TNBC患者中,淋巴结转移和肿瘤分期与TNBC患者5年生存预后有统计学差异(P<0.05)。肿瘤大小和淋巴结转移与TNBC患者无病生存时间及总生存时间均呈显著负相关(P<0.05)。结论 TNBC患者5年生存率与淋巴结转移、肿瘤分期有关,肿瘤大小和淋巴结转移是影响TNBC患者预后的独立危险因素。
Objective To analyze the correlation between clinicopathological features and prognosis in triple negative breast cancer (TNBC). Methods The clinical and pathological features of 48 cases of TNBC patients with negative expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 were retrospectively analyzed. The effects of clinicopathological features on the prognosis of 5-year patients were analyzed. Results Among the 48 patients with TNBC, the 5-year survival and lymph node metastasis and tumor stage were significantly different from those of TNBC patients (P <0.05). There was a significant negative correlation between tumor size and lymph node metastasis and disease-free survival and overall survival time in patients with TNBC (P <0.05). Conclusion The 5-year survival rate of TNBC patients is related to lymph node metastasis and tumor stage. The size of tumor and lymph node metastasis are independent risk factors for prognosis of patients with TNBC.