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目的：为验证“正虚挟瘀”是中医衰老的重要原因／ 机制的可靠性及合理性，观察了补肾健脾化瘀天年安对老年小鼠免疫功能、自由基代谢及全血粘度的影响。方法：老年小鼠连续４ 周灌服天年安后，检测腹腔巨噬细胞产生的白细胞介素１（ ｉｎｔｅｒｌｅｕｋｉｎ１ ，ＩＬ１）、脾淋巴细胞产生的白细胞介素２（ｉｎｔｅｒｌｅｕｋｉｎ２，ＩＬ２） 的活性、全血粘度的变化、肝脑的脂质过氧化（ｌｉｐｉｄ ｐｅｒｏｘｉｄｅｓ，ＬＰＯ） 含量以及红细胞清除自由基酶的活性，如超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅ ｄｉｓｍｕｔａｓｅ，ＳＯＤ） 、过氧化氢酶（ｃａｔａｌａｓｅ，ＣＡＴ） 、谷胱甘肽过氧化物酶（ｇｌｕｔａｔｈｉｏｎｅ ｐｅｒｏｘｉｄａｓｅ，ＧＳＨＰｘ）。结果：老年小鼠ＩＬ１、ＩＬ２ 的产生以及ＳＯＤ、ＣＡＴ、ＧＳＨＰｘ 均明显低于青年小鼠，而肝脑产生的ＬＰＯ 及全血粘度则明显增加。给药后，上述指标均可明显得到改善。结论：说明老年机体确“虚”和“瘀”并存，进一步为我们的观点提供了实验依据；同时也说明ＩＬ２ 的产生能力降低除与Ｔ 细胞本身有关外，还与巨噬细胞、自由基代谢等因素有关。
OBJECTIVE: To verify the validity and rationality of “positive imaginary” as an important cause/mechanism of aging in traditional Chinese medicine, observe the effect of Bushen Jianpi Huayu Tiannian on immune function, free radical metabolism and whole blood viscosity of old mice. influences. METHODS: Old mice were treated with Tiannian for 4 consecutive weeks. Interleukin-1 (IL-1) produced by peritoneal macrophages and interleukin-2 (interleukin-2) produced by spleen lymphocytes were examined. IL 2) activity, changes in whole blood viscosity, lipid peroxides (LPO) content in liver and brain, and activity of scavenging free radicals in red blood cells, such as superoxide dismutase (SOD) Catalase (CAT), glutathione peroxidase (GSH-Px). Results: The production of IL1 and IL2 and SOD, CAT, and GSHPx in aged mice were significantly lower than those in young mice. The LPO and whole blood viscosity of liver and brain were significantly increased. After administration, the above indicators can be significantly improved. Conclusion: It shows that the coexistence of “deficiency” and “deficiency” in the elderly body provides experimental evidence for our point of view. It also shows that the reduction of IL-2 production capacity is related to macrophages and freedom, in addition to T cells themselves. Base metabolism and other factors.