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目的：为了解我院食管癌手术患者围术期预防性使用抗菌药物情况，评价围术期使用抗菌药物使用是否合理。方法回顾性调查我院胸外科2013年10月～2014年9月食管癌手术患者病历共计272份，分析围术期抗菌药物使用的情况。结果本次调查手术患者共计272例，其中男性209例，占76．83％；女性63例，占23．17％；最大年龄78岁，最小年龄39岁，平均年龄60．81±7．32岁。267例术前预防性使用抗菌药物，5例术前未使用；术后预防性抗菌药物使用时间1～10d，平均时间为4．23±3．0天。预防性使用抗菌药物种类排名前三位的分别是头孢呋辛、阿莫西林克拉维酸、头孢美唑。102例术后改为治疗性使用抗菌药物，排名前三位的为哌拉西林他唑巴坦、阿米卡星、头孢他啶，治疗使用抗菌药物平均时间7．00±3．10天；抗菌药物主要以一联使用为主。结论食管癌手术患者围术期抗菌药物使用欠规范，应加强食管癌围术期抗菌药物使用的管理，合理选择抗菌药物。“,”Objective To understand the perioperative prophylactic use of antibiotics about esophageal carcinoma patients in our hospital,Evaluate the rationality of the perioperative use of antimicrobial drugs.Methods A retrospective survey of thoracic surgery patients in our hospital from October 2013 to September 2014 ,The total of patients with esophageal carcinoma surgery are 272,copies of medical records,analyze the situation of perioperative antimicrobial drug use.Results A total of 272 cases of surgical patients in this survey,male 209 cases,accounting for 76.83%;female 63 cases,accounting for 23.17%;maximum age of 78 years old,the minimum age of 39 years,mean age 60.81 ±7.32 years old.267 cases of preoperative prophylactic use of antibiotics,five cases is not used before the surgery;prophylactic use of antibiotics time from 1 day to 10 day,the average time was 4.23 ±3.0 days.the top three types of Prophylactic use of antibiotics were cefuroxime,amoxicil in clavulanic acid,Cefmetazole.102 cases change to therapeutic use of antimicrobial drugs,the top three are piperacil in and tazobactam,amikacin, ceftazidime,Therapeutic use of antibiotics average time 7.00 ±3.10 days;Combined use antibacterial drug mainly one combined .Conclusions the perioperative use of antibiotics about Esoph-ageal carcinoma surgery patients are not standardized ,we should strengthen the management about the use of perioperative antimicrobial drug,and make a reasonable choice of using antibiotics.