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目的探讨注射用丹参多酚酸盐治疗冠心病心绞痛的疗效。方法选取冠心病心绞痛患者98例,随机分为两组,每组49例,常规西药治疗基础上对照组常规口服复方丹参滴丸(天津天士力制药股份有限公司,国药准字Z10950111)治疗,每次10粒,3次/d。试验组采用注射丹参多酚酸盐治疗,静脉滴注,每次200 mg,用5%葡萄糖溶液500 ml配伍使用,1次/d。两组均治疗两周。观察两组患者治疗前后临床症状、心绞痛发作次数以及发作持续时间,比较其临床疗效,并观察两组不良发应情况。结果两组治疗前后心绞痛发作次数和持续时间比较,P<0.05,差异有统计学意义。与对照组比较,试验组治疗后心绞痛发作次数减少和持续时间缩短,差异有统计学意义(P<0.05)。两组临床疗效比较,P<0.05。试验组患者不良反应发生率(8.16%)明显低于对照组(34.69%),差异有统计学意义(P<0.05)。结论注射丹参多酚酸盐治疗冠心病心绞痛临床疗效明显且安全,优于口服复方丹参滴丸。
Objective To investigate the curative effect of salvia miltiorrhiza polyphenols for angina pectoris of coronary heart disease. Methods A total of 98 patients with coronary heart disease and angina pectoris were randomly divided into two groups (n = 49 in each group). On the basis of conventional western medicine, the control group was given routine oral compound Danshen Dripping Pill (Tianjin Tasly Pharmaceutical Co., Ltd., Zhunyizhenzi Z10950111) 10 capsules, 3 times / d. The experimental group was treated with Salviae miltiorrhizae polyphenols by injection, 200 mg each time. The mice were treated with 500 ml of 5% dextrose solution for 1 time / d. Both groups were treated for two weeks. The clinical symptoms, the number of angina attacks and the duration of attack were observed before and after treatment in both groups. The clinical curative effects were compared and the adverse reactions were observed. Results Before and after treatment, the number and duration of angina pectoris were compared, P <0.05, the difference was statistically significant. Compared with the control group, the number and the duration of angina pectoris in experimental group decreased after treatment, the difference was statistically significant (P <0.05). The clinical efficacy of two groups, P <0.05. The incidence of adverse reactions in the experimental group (8.16%) was significantly lower than that in the control group (34.69%), the difference was statistically significant (P <0.05). Conclusion Salviae miltiorrhizae is effective and safe in the treatment of angina pectoris of coronary heart disease, which is better than oral compound danshen dripping pills.