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目的 :筛选治疗芥子气皮肤损伤的有效药物。方法 :以刚断奶小猪为动物模型 ,染毒创面经连续 1周分别外用速愈平、医用几丁糖、肤康霜、喜疗妥 4种药物后 ,观察创面形态学和组织病理学变化 ,并取创面活检标本用流式细胞术分析细胞DNA周期变化来评价细胞增殖活力。结果 :大体形态学发现 ,治疗组与对照组相比 ,红斑糜烂期出现时间、程度和范围无明显差别 ,但其中速愈平、几丁糖、肤康霜 3组创面结痂时间早 ,愈合时间短 ;组织病理学观察也表明这 3组创面细胞和纤维增生活跃 ,而喜疗妥组和对照组相比无明显差别 ;流式细胞术分析结果显示速愈平、几丁糖、肤康霜 3组的创面S +G2 +M期细胞比例显著高于喜疗妥组和对照组。结论 :速愈平、几丁糖、肤康霜对猪皮肤芥子气损伤创面愈合有一定的促进作用。
Objective: To screen effective drugs for the treatment of mustard skin injury. Methods: The weaned piglets were used as the animal model. The wounds were observed for wound morphological and histopathological changes after four weeks of topical application of fasting, medical chitosan, , And wound biopsy specimens were analyzed by flow cytometry cell cycle changes in DNA to assess cell proliferation activity. Results: The general morphological findings showed that there was no significant difference in the time, extent and range of erythema erosions between the treatment group and the control group. However, the wound healing time of the three groups were earlier, healing Time short; histopathological observation also showed that these three groups of wounds and fibroblasts proliferative activity, and compared with the control group, no significant difference; flow cytometry analysis showed that the fast healing, chitosan, skin health The proportion of cells in the S + G2 + M phase in the frost-3 group was significantly higher than that in the xylight group and the control group. Conclusion: Suyuping, Chitosan and Fukangshuang can promote the wound healing of pig mustard gas.