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HPMC(羟丙基甲基纤维素)作为一种优良的粘合剂、助溶出剂和薄膜包衣材料,正逐渐在我国制剂工业中被推广应用。HPMC在水中能缓设溶解,且不受介质pH的影响,利用这种特性HPMC还可以用作不溶性骨架绥释片的致孔剂、亲水性凝胶缓释片的骨架材料和缓释制剂的包衣材料等,此外还可与难溶性药物制成固体分散剂,提高药物的溶出度、生物利用度以及药品质量的稳定性。美国Forest厂研究利用湿热处理HPMC,使之水解和氧化而获得一种改良的HPMC。处理前的HPMC(Methocel E50)羰基含量低于0.9％(W/W),羧基含
HPMC (hydroxypropylmethyl cellulose) as an excellent binder, aids and film coating materials, is gradually being applied in the pharmaceutical industry in our country. HPMC in the water can ease the dissolution, and is not affected by the media pH, the use of this feature HPMC can also be used as a insoluble skeleton rehabiliters porogen, hydrophilic gel sustained-release tablets skeleton material and sustained release formulations Of the coating material, in addition can also be made with the insoluble drug solid dispersant to improve drug dissolution, bioavailability and drug quality and stability. Forest plant in the United States to study the use of wet heat treatment of HPMC, hydrolysis and oxidation to obtain a modified HPMC. The carbonyl content of the pre-treated HPMC (Methocel E50) was less than 0.9% (w / w)