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支气管粘液表皮样癌罕见,占其发生肿瘤的2.5％,占原发性肺癌的20％。国内多为个案报道,我们共收集14例,现报告如下。14例中,男11例,女3例,平均年龄38岁,左肺11例,右肺3例,主要发生在主支气管及叶支气管旁,病程1个月～4年,主要表现为胸闷,咳痰带血。X线检查易误诊为结核。病程表现:14例中,低度恶性9例,肿瘤2～scm,平均25cm,镜检,瘤组织由表皮样细胞中间细胞和粘液细胞组成,无异形性。粘液上皮形成大小不一的扩张粘液腔,奥辛兰粘液染色呈兰绿色,癌胚抗原免疫酶标染色显示中间细胞阴性,粘液细胞及腔内呈棕色颗粒状。高度恶性5例,肿瘤2～9cm,平均4.5cm,镜检;瘤细胞以表皮样细胞和中间细胞为主,异形明显。粘液上皮基本消失,只保留粘液池分布在实性细胞巢之间,奥辛兰染色粘液池呈少许兰绿色,癌胚抗原显示部分棕色颗粒状。角蛋白染色二者皆显示中间细胞和粘液上皮阳性。
Bronchial mucoepidermoid carcinoma is rare, accounting for 2.5% of the tumors that occur, accounting for 20% of primary lung cancer. Domestic cases are mostly reported. We collected a total of 14 cases. The report is as follows. In 14 cases, there were 11 males and 3 females, with an average age of 38 years, 11 cases of left lung, and 3 cases of right lung, which mainly occurred in the main bronchus and leaf bronchi. The disease duration ranged from 1 month to 4 years, and the main manifestation was chest tightness. Cough blood. X-ray examination is often misdiagnosed as tuberculosis. Course of manifestation: 14 cases, 9 cases of low-grade malignancy, tumors 2 ~ scm, average 25cm, microscopic examination, tumor tissue consists of epidermal-like cells and mucinous cells in the middle, no abnormality. The mucus epithelium forms dilated mucus chambers of varying sizes. The Auslan mucus stains blue-green. Carcinoembryonic antigen immunolabeling reveals that the intermediate cells are negative, and the mucinous cells and lumen are brownish-granular. Highly malignant in 5 cases, tumors 2 ~ 9cm, an average of 4.5cm, microscopic examination; tumor cells with epidermoid cells and intermediate cells, the obvious shape. The mucous epithelium disappeared, leaving only the mucus pool between the nests of solid cells. The Oculus stained mucus pool was a little blue-green, and the carcinoembryonic antigen showed some brown granules. Both keratin stains show positive intermediate cells and mucous epithelium.