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目的 评价小剂量卡介苗 (BCG)预防浅表性膀胱癌永不复发的疗效和安全性。方法 对 40例浅表性膀胱癌患者行经尿道膀胱肿瘤电切术或膀胱部分切除术 ,术后定期应用小剂量BCG(6 0mg)膀胱内灌注 ,每次药物在膀胱内保留 2小时。结果 40例患者均获得 2年随访 ,无肿瘤复发 33例 (82 .5 % ) ,复发 7例。未见有全身性药物不良反应 ,仅 10例膀胱灌药后出现短时间轻度膀胱刺激症状。结论 小剂量BCG膀胱内灌注预防浅表性膀胱癌术后复发疗效满意 ,病人耐受性好 ,副作用小 ,值得临床推广应用。
Objective To evaluate the efficacy and safety of low-dose BCG in preventing recurrence of superficial bladder cancer. Methods Forty patients with superficial bladder cancer undergoing transurethral resection of the bladder tumor or partial resection of the bladder were treated with low dose BCG (60 mg) intravesical instillation after operation. Each drug was kept in the bladder for 2 hours. Results All the 40 patients were followed up for 2 years. There were 33 cases (82.5%) without tumor recurrence and 7 cases relapsed. No systemic adverse drug reactions were observed. Only a brief period of mild bladder irritation occurred after bladder irrigation in only 10 cases. Conclusion Intravesical instillation of low dose BCG is effective in preventing postoperative recurrence of superficial bladder cancer. Patient is well tolerated and has few side effects. It is worthy of clinical application.