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目的观察小剂量米非司酮治疗围绝经期功血的疗效。方法选择2013年8月-2014年11月在医院治疗的围绝经期功血的患者共106例,随机分为对照组和观察组各53例,对照组在诊断性刮宫之后予去氧孕烯炔雌醇治疗;观察组予小剂量的米非司酮和去氧孕烯炔雌醇治疗。比较2组临床疗效及不良反应发生情况。结果观察组总有效率94.3%明显优于对照组的79.2%,差异有统计学意义(P<0.05)。2组患者均无肝肾功能损害不良反应发生,对照组出现头晕3例,胃部不适6例,恶心3例,不良反应发生率22.6%;观察组出现头晕5例,胃部不适5例,恶心3例,不良反应发生率24.5%。2组比较差异无统计学意义(P>0.05)。结论米非司酮治疗围绝经期功血可有效改善患者出血情况,改善激素水平,疗效显著,并且安全可靠,无严重不良反应发生,值得临床应用。
Objective To observe the curative effect of low dose mifepristone on peri - menopausal dysfunctional uterine bleeding. Methods A total of 106 patients with peri-menopausal dysfunctional uterine bleeding who were treated in the hospital from August 2013 to November 2014 were randomly divided into control group and observation group with 53 cases each. The control group received desogestrel Ethinyl estradiol treatment; the observation group to a small dose of mifepristone and desogestrel ethinyl estradiol treatment. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate was 94.3% in the observation group was significantly better than 79.2% in the control group, the difference was statistically significant (P <0.05). There were no adverse reactions of liver and kidney dysfunction in the two groups. There were 3 cases of dizziness, 6 cases of stomach discomfort, 3 cases of nausea and 22.6% of adverse reactions in the control group. In the observation group, 5 cases of dizziness, 5 cases of stomach discomfort, Nausea in 3 cases, the incidence of adverse reactions 24.5%. There was no significant difference between the two groups (P> 0.05). Conclusion Mifepristone treatment of peri-menopausal dysfunctional uterine bleeding can effectively improve the patient’s bleeding, improve hormone levels, the effect is significant, and safe and reliable, no serious adverse reactions, it is worth clinical application.