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目的:探讨宫颈浸润癌及癌前病变与女性年龄的关系。方法:2013年45 430例已婚妇女在天津金域医学检验中心进行了宫颈浸润癌筛查。首先进行TCT检测,然后对TCT检测结果阳性病例行HC2HPV-DNA检测,两项结果为阳性者,行阴道镜及宫颈活检。对检测结果按照年龄分组进行统计分析。结果:45 430例中,ASCUS及以上者共2 234例(4.92%),而30~39岁组、40~49岁组及50~59岁组的发病率较高。2 234例中HC2HPV-DNA阳性者1 572例(70.37%)。20~29岁组HPV感染率最高,占该年龄段ASCUS及以上者总人数的83.52%。宫颈浸润癌及癌前病变发病率分别为0.16%及1.55%,其中40~49岁组及50~59岁组宫颈浸润癌发病率最高,均为0.28%,远高于其他年龄组,差异有统计学意义(P<0.05)。30~39岁组及40~49岁组的癌前病变发病率分别是1.86%和1.82%,远高于其他年龄组,差异有统计学意义(P<0.05)。与宫颈浸润癌高发年龄相比,癌前病变高发年龄明显提前。结论:天津市已婚妇女的癌前病变的高发年龄为30~49岁,而宫颈浸润癌的高发年龄为40~59岁。
Objective: To investigate the relationship between cervical cancer and precancerous lesions and female age. Methods: In 2013 45 430 married women were screened for invasive cervical cancer at the Tianjin Jinyu Medical Laboratory Center. The first TCT test, and then positive TCT test results of HC2HPV-DNA test, the two were positive, colposcopy and cervical biopsy. The test results were grouped by age for statistical analysis. Results: Of the 45 430 cases, 2 234 (4.92%) had ASCUS and above, while the incidence was higher in 30-39 years old, 40-49 years old group and 50-59 years old group. There were 1 572 (70.37%) cases of HC2HPV-DNA positive in 2 234 cases. The highest HPV infection rate was found in 20-29 age group, accounting for 83.52% of the total number of ASCUS and above in this age group. Cervical invasive carcinoma and precancerous lesions were 0.16% and 1.55%, respectively, of which the incidence of cervical invasive carcinoma was highest in 40-49 years old group and 50-59 years old group, both of which were much higher than other age groups Statistical significance (P <0.05). The incidence of precancerous lesions in 30-39 years old group and 40-49 years old group were 1.86% and 1.82%, which were much higher than other age groups (P <0.05). Compared with the high incidence of invasive cervical cancer, precancerous lesions were significantly advanced age. Conclusion: The incidence of precancerous lesions in married women in Tianjin is 30 ~ 49 years old, while the incidence of cervical cancer is 40 ~ 59 years old.