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脑卒中是导致中老年人群死亡最主要原因之一,其具有较高的致死率和致残率,且每年的发病率呈逐年上升的趋势,严重危害人类的生命和健康,因此寻找有效的诊断及治疗脑卒中的靶点具有重要意义。硫氧还蛋白(Trx)是细胞内主要的硫醇还原剂,通过调节细胞内氧化还原状态,参与细胞内多种信号通路转导过程,具有二硫化物还原酶活性,通过抗氧化效应,减轻脑卒中后神经元氧化应激损伤。硫氧还原蛋白相互作蛋白(TXNIP)是Trx的内源性抑制剂,通过绑定/抑制Trx的活性,破坏细胞内氧化还原平衡,促进氧化应激,而抑制或敲除TXNIP具有明显的神经保护作用。最新研究表明Trx/TXNIP可经多种途径参与脑卒中病理生理过程。本文通过分析Trx和TXNIP的研究现状,以及探讨Trx系统在中枢神经系统中的定位和Trx系统在缺血性脑卒中的研究进展,展望Trx/TXNIP参与脑卒中的病理生理过程的信号途径,拟对Trx/TXNIP在脑卒中的作用机制进行综述,为脑卒中的治疗提供新思路。
Stroke is one of the most important causes of death in middle-aged and elderly people. It has a high mortality rate and morbidity, and the annual incidence rate is increasing year by year, which seriously endangers the life and health of human beings. Therefore, to find an effective diagnosis And the treatment of stroke target is of great significance. Thioredoxin (Trx), a key thiol reductant in cells, participates in the transduction of various signaling pathways in the cell by regulating intracellular redox status and has disulfide reductase activity, which is relieved by the anti-oxidant effect Post-stroke neuronal oxidative stress injury. Thioredoxin (TXNIP), an endogenous inhibitor of Trx, inhibits or knocks out TXNIP by binding / inhibiting Trx activity, disrupting intracellular redox balance, and promoting oxidative stress Protective effects. Recent studies show that Trx / TXNIP can participate in the pathophysiology of stroke in many ways. In this paper, by analyzing the current status of the study of Trx and TXNIP, as well as to explore the Trx system in the central nervous system localization and Trx system in ischemic stroke, and looking forward to Trx / TXNIP signaling pathways involved in the pathophysiology of stroke, to be The mechanism of action of Trx / TXNIP in stroke is reviewed, providing new ideas for the treatment of stroke.