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目的研究2009-2013年某医院临床分离鲍氏不动杆菌的分布及耐药性的变迁。方法回顾分析2009-2013年我院住院患者标本中分离的鲍氏不动杆菌的分布情况及其药敏试验结果,采用仪器法和纸片扩散法检测鲍氏不动杆菌对常用10种抗菌药物的耐药性,分析5年来鲍氏不动杆菌的分布特点及耐药性变迁。结果 5年间共分离到鲍氏不动杆菌1 200株,2009-2011年其数量和所占总分离菌株的构成比呈逐年递增。标本类型中痰、分泌物和血占分离标本的前3位,痰标本最常见,占82.83%。鲍氏不动杆菌对亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦的耐药率呈逐年上升趋势。对环丙沙星耐药率最高,平均达77.27%。结论 5年来鲍氏不动杆菌对部分抗菌药物的耐药性呈升高趋势,应加强鲍氏不动杆菌的耐药性监测,依据体外药敏结果合理使用抗菌药物。
Objective To study the distribution and drug resistance changes of Acinetobacter baumannii in a hospital from 2009 to 2013. Methods The distribution of Acinetobacter baumannii isolated from hospitalized patients in our hospital from 2009 to 2013 and the drug susceptibility test results were retrospectively analyzed. Acinetobacter baumannii was tested by instrument method and disk diffusion method for 10 kinds of commonly used antimicrobial drugs Of the drug resistance, analysis of 5 years Acinetobacter baumannii distribution characteristics and drug resistance changes. Results A total of 1 200 strains of Acinetobacter baumannii were isolated in 5 years. The numbers of the strains and the proportions of the total isolates were increasing year by year from 2009 to 2011. Sputum, secretions and blood samples accounted for the first three cases of separation specimens, the most common sputum specimens, accounting for 82.83%. Acinetobacter baumannii resistance to imipenem, piperacillin / tazobactam, cefoperazone / sulbactam showed a rising trend year by year. Ciprofloxacin resistance rate of the highest, an average of 77.27%. Conclusion Acinetobacter baumannii showed an increasing trend of resistance to some antibiotics over the past five years. The drug resistance of Acinetobacter baumannii should be strengthened and antimicrobial drugs should be used reasonably according to the drug susceptibility results in vitro.