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了解血管新生机制的研究进展,以便为防治固体癌肿及缺血性疾病提供新的科学依据。通过英特网检索,得知胎盘生长因子(PIGF)是血管内皮增长因子(VEGF)家族中的一员。与VEGF及G-CSF一样在骨髓中伴随基质金属蛋白酶-9(MMP-9)活性升高,激发末梢血中造血干细胞。具有可塑性的骨髓间质细胞控制胚胎细胞定向分化为血管内皮干细胞,成为供体细胞,为细胞移植提供足够的供体源,因此骨髓细胞已成为学者的关注目标。从目前的控制血管新生机制的研究进展可预见,人为控制血管新生是可能的,看到了用抑制血管新生防治固体癌症,用促进血管新生防治缺血性疾病带来的曙光。
To understand the mechanism of angiogenesis research advances in order to provide a new scientific basis for the prevention and treatment of solid cancer and ischemic diseases. Retrieved from the Internet, placental growth factor (PIGF) is a member of the vascular endothelial growth factor (VEGF) family. Like VEGF and G-CSF in the bone marrow accompanied by increased activity of matrix metalloproteinase-9 (MMP-9), stimulate peripheral blood hematopoietic stem cells. The plasticity of bone marrow stromal cells to control the directional differentiation of embryonic cells into vascular endothelial stem cells, become donor cells, provide sufficient donor source for cell transplantation, so bone marrow cells has become the focus of scholars. From the current research on the mechanism of controlling angiogenesis, it is foreseeable that artificially controlling angiogenesis is possible, and the dawn of prevention and treatment of solid cancers by inhibiting angiogenesis and prevention of ischemic diseases by promoting angiogenesis has been observed.