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目的:探讨冠心病患者血浆脑钠尿肽(BNP)水平与冠状动脉支架内再狭窄的关系。方法:选择317例接受冠状动脉支架植入术(PCI)以及术后1年内再次接受冠状动脉造影(CAG)检查的患者,分为再狭窄和无再狭窄组,分别在PCI术前、出院前和复查CAG前测定血浆BNP水平,两组患者分别比较相应的BNP水平。结果:再狭窄组PCI术前、出院前及复查CAG前的BNP水平与无再狭窄组分别进行比较,差异有统计学意义(P<0.05),多因素logistic回归分析结果,血浆BNP水平是预测再狭窄的独立危险因子(均P<0.01)。结论:血浆BNP水平与PCI术后再狭窄密切相关,有可能作为再狭窄的有用预测指标。
Objective: To investigate the relationship between plasma brain natriuretic peptide (BNP) and coronary stent restenosis in patients with coronary heart disease. Methods: A total of 317 patients undergoing coronary artery stenting (PCI) and undergoing coronary angiography (CAG) within 1 year after surgery were enrolled. Patients were divided into two groups: restenosis group and non-restenosis group. Before PCI, Plasma BNP levels were measured before CAG, and the corresponding BNP levels were compared between the two groups. Results: The levels of BNP before resuscitation and before CAG were compared with those without restenosis in restenosis group (P <0.05). The multivariate logistic regression analysis and plasma BNP level were the predictors Restenosis independent risk factors (all P <0.01). Conclusion: Plasma BNP level is closely related to restenosis after PCI, which may be used as a useful predictor of restenosis.