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目的 :探讨小儿难治性肾病的有效治疗措施、疗效与病理类型的关系。 方法 :总结了使用甲泼尼龙冲击治疗的 30例小儿难治性肾病的经验。甲泼尼龙 15～ 30 mg/ ( kg· d) ,共 3天 ,间歇 4～ 7天后用第二个疗程 ,疗程间隙期用泼尼松 1.5～ 2 mg/ ( kg· d)口服 ,疗程结束后 ,泼尼松按中长程疗法治疗。 结果 :30例肾病综合征 14例完全缓解 ,4例部分缓解 ,总有效率为 6 0 % ,无一例出现严重的不良反应。 结论 :甲泼尼龙冲击治疗小儿难治性肾病是一种安全有效的方法 ,特别是对 Ms PGN、MPGN、MCNS更佳
Objective: To explore the effective treatment of refractory nephropathy in children, the relationship between curative effect and pathological type. Methods: The experience of 30 children with refractory nephropathy treated with methylprednisolone was summarized. Methylprednisolone 15 ~ 30 mg / (kg · d), a total of 3 days, intermittent 4 to 7 days after the second course of treatment, the course of the gap with prednisone 1.5 ~ 2 mg / (kg · d) After the long-term treatment of prednisone. Results: In the 30 cases of nephrotic syndrome, 14 cases were completely relieved, 4 cases partially relieved, and the total effective rate was 60%. No serious adverse reaction occurred. CONCLUSION: Methylprednisolone is a safe and effective treatment for refractory nephropathy in children, especially for Ms PGN, MPGN and MCNS