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目的探讨γ-谷氨酰转肽酶(GGT)与高尿酸血症(HUA)发病之间的关系。方法本研究选取“山东多中心健康管理纵向观察队列”中26 006名体检者作为基线进行随访,构建结局为HUA的研究队列,GGT分为4个水平(由低到高分别为Q1、Q2、Q3、Q4),采用Cox比例风险回归模型分析GGT不同水平与HUA发病之间的关系。结果 HUA发病密度为74.7/1 000人年。仅对年龄进行调整时,GGT不同水平各组(Q2、Q3、Q4)与低水平组(Q1)的相对危险度RR分别为1.64(95%CI:1.46~1.84,P<0.001)、2.24(95%CI:2.00~2.50,P<0.001)、2.68(95%CI:2.41~2.99,P<0.001);调整年龄、体质量指数、收缩压、甘油三酯、总胆固醇、高密度脂蛋白、血肌酐后RR值分别为1.20(95%CI:1.04~1.38,P<0.001)、1.43(95%CI:1.24~1.64,P<0.001)、1.51(95%CI:1.31~1.74,P<0.001);进一步调整吸烟和饮酒因素后RR值分别为1.19(95%CI:1.04~1.37,P<0.001)、1.41(95%CI:1.23~1.62,P<0.001)、1.49(95%CI:1.29~1.72,P<0.001)。结论 GGT是HUA发病的独立危险因素,随着GGT水平的升高,HUA的发病风险增大。
Objective To investigate the relationship between γ-glutamyl transpeptidase (GGT) and the pathogenesis of hyperuricemia (HUA). Methods In this study, we selected 26 006 physical examiners from Shandong Multicenter Health Management Longitudinal Observation Team as the follow-up study to establish a cohort of patients with HUA. The GGT was divided into 4 levels (from low to high, Q1, Q2, Q3 and Q4). Cox proportional hazards regression model was used to analyze the relationship between different GGT levels and HUA incidence. Results The incidence of HUA was 74.7 / 1000 person-years. The relative risk (RR) of different levels of GGT (Q2, Q3, Q4) and low level group (Q1) were 1.64 (95% CI: 1.46-1.84, P <0.001), 2.24 (95% CI: 2.00-2.50, P <0.001); 2.68 (95% CI: 2.41-2.99, P <0.001); adjusted for age, body mass index, systolic blood pressure, triglycerides, total cholesterol, high density lipoprotein, The serum creatinine RR was 1.20 (95% CI: 1.04-1.38, P <0.001), 1.43 (95% CI: 1.24-1.64, P <0.001) ). The adjusted RR of smoking and drinking were 1.19 (95% CI: 1.04-1.37, P <0.001), 1.41 (95% CI: 1.23-1.62, P <0.001) ~ 1.72, P <0.001). Conclusion GGT is an independent risk factor for HUA. The risk of HUA increases with the increase of GGT level.