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目的:探讨国产辛伐他汀对原发性高胆固醇血症的调脂作用。方法:观察了42例高胆固醇血症患者,根据血清TC水平随机分验证组29例及对照组13例,验证组服用国产辛伐他汀,对照组服用进口舒降之,均服10mg/日,疗程均为8周。结果:验证组与对照组服药8周,降血清总胆固醇(TC)分别为24.9%和24.7%;降低密度脂蛋白胆固醇(LDL-C)分别为34.7%和34.9%;降甘油三酯(TG)分别为24.9%和23.9%;降(TC-HDL-C)/HDLC分别为41.7%和41.2%;升高高密度脂蛋白胆固醇(HDL-C)分别为15.7%和16.3%,与治疗前比均有显著或极显著差异(P<0.05或P<0.01)。验证组及对照组8周总有效率TC分别为97%和92%;TG分别为70%和63%;(TC-HDL-C)/HDL-C分别为97%和100%;HDL-C男女均为100%,其降低及升高幅度两组间均无明显差别(均P>0.05)。服药过程中验证组出现肌肉酸痛和轻微头痛各1例;对照组出现肌肉酸痛及肩关节痛各1例未予治疗,自行缓解,均比较顺利地完成疗程。结论:国产辛伐他汀是一种高效,安全调脂剂。
Objective: To investigate the effect of domestic simvastatin on lipid-lowering effect of primary hypercholesterolemia. Methods: Forty-two patients with hypercholesterolemia were randomly divided into control group (n = 29) and control group (n = 13). The patients in the validation group took domestic simvastatin and the control group took 10 mg / The course of treatment is 8 weeks. Results: The serum total cholesterol (TC) of the test group and the control group were 24.9% and 24.7%, respectively, and the levels of LDL-C were 34.7% and 34.9% ) Were 24.9% and 23.9% respectively; TC-HDL-C / HDLC were 41.7% and 41.2% respectively; HDL-C was 15.7% and 16.3% (P <0.05 or P <0.01). The total effective rate (TC) was 97% in the validation group and 92% in the control group at 8 weeks, with TCs of 70% and 63%, respectively (TC-HDL-C and HDL- Both men and women were 100%, the decrease and increase in both groups were no significant difference (all P> 0.05). In the course of taking the medicine, there were 1 case of muscle ache and slight headache in the test group. One case of muscle soreness and shoulder joint pain in the control group was treated without any treatment and relieved spontaneously, and the course of treatment was completed smoothly. Conclusion: Domestic simvastatin is an effective and safe lipid-adjusting agent.