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背景 因为强烈的骨髓抑制以及生存期的延长,血液学及肿瘤学患者依赖于输血维持生存的时间越来越长。学者们提倡对这些受血患者输血时血型抗原应作ABO和D以外的血型应相合。一项回顾性研究,调查10年内564例恶性血液病患者发生针对红细胞抗原的同种免疫情况。研究设计与方法 来自一家医院,1987～1996年间所有被诊断为恶性骨髓和淋巴增殖性疾病患者(n=1,066),从医院计算机血库档案中得到的输血记录和免疫血液学研究。按抗体的形成与输血关联,分析影响这种相关性的因素。结果 在51例患者中发现有71种抗体。总的同种免疫率为9％,50％的抗体形成于输入13血单位后,一旦患者产生了一种抗体,则其它抗体形成的概率上升3.3倍,大多数发现的抗体为抗-c、抗-E以及抗-K。4例患者
Background Due to strong bone marrow suppression and prolonged survival, patients in hematology and oncology rely on blood transfusions to survive longer. Scholars advocate that blood group antigens should be matched for blood types other than ABO and D when transfusion is performed on these blood recipients. A retrospective study of 564 patients with hematologic malignancies over a 10 year period showed an alloimmunization against RBC antigen. Study Design and Methodology A hospital from 1987 to 1996 was diagnosed with malignant bone marrow and lymphoproliferative disease (n=1,066). Transfusion records and immunohematology studies were obtained from hospital blood bank archives. According to the formation of antibodies and blood transfusion, analyze the factors that affect this correlation. Results 71 antibodies were found in 51 patients. The total immunization rate was 9%. After 50% of the antibodies were formed at the input of 13 blood units, once the patient developed an antibody, the probability of formation of other antibodies increased by 3.3 times. Most of the antibodies found were anti-c, Anti-E and anti-K. 4 patients