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目的评估发病前使用他汀类药物对急性缺血性卒中发病时症状严重程度及出院时功能转归的影响。方法回顾性分析2006年1月至10月上海交通大学医学院附属新华医院神经内科住院治疗的185例急性缺血性卒中患者的临床资料,依据发病前是否已使用他汀类药物分为他汀治疗组(57例)与非他汀治疗组(128例),对比两组的一般资料、血管危险因素、牛津郡临床分型、入院时美国国立卒中量表(NIHSS)评分、治疗方法、出院时Barthel指数等。结果他汀治疗组入院时NIHSS评分低于非他汀治疗组(6.0对13.0,P<0.01),出院时功能转归良好病例百分比高于非他汀治疗组(77.2%对41.1%,P<0.01)。非他汀治疗组中服用抗血小板药物者与未合并用药者比较,入院时NIHSS评分和出院时达到功能转归良好的病例百分比差异均有显著性意义(P均<0.05)。出院时功能转归良好与发病前使用他汀类药物相关(OR=5.784,P<0.01)。结论发病前使用他汀类药物能减轻急性缺血性卒中症状及改善出院时功能转归。
Objective To assess the effect of statins before onset on the severity of symptoms and functional outcome at discharge at the onset of acute ischemic stroke. Methods The clinical data of 185 acute ischemic stroke patients hospitalized in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine between January 2006 and October 2006 were retrospectively analyzed. According to whether statins were used prior to onset, the patients were divided into statin group (57 cases) and non-statin treatment group (128 cases). The general data, vascular risk factors, Oxfordshire clinical classification, NIHSS score, treatment method, Barthel index Wait. Results The NIHSS score of statin group was significantly lower than that of non-statin group (6.0 vs 13.0, P <0.01). The percentage of patients with good outcome at discharge was higher than that of non-statin group (77.2% vs 41.1%, P <0.01). In the non-statin group, those taking antiplatelet drugs had significantly different percentages of NIHSS scores at admission and those who achieved good outcome at discharge (P <0.05). Good functional outcome at discharge was associated with statin use before onset (OR = 5.784, P <0.01). Conclusions The use of statins before onset can reduce acute ischemic stroke symptoms and improve functional outcome at discharge.