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注射半胱胺后大鼠下丘脑CRF和血浆皮质酮含量均明显升高,表明半胱胺可激活下丘脑—垂体—肾上腺皮质(HPA)系统。实验组动物预先连续注射4天地塞米松造成肾上腺皮质萎缩,在停药后第5天和第12天分别给予半胱胺,所诱发的溃疡均较未经地塞米松预处理的对照组动物明显减轻,它们的溃疡指数分别为对照组的20％和19％(P<0.01)。结果提示,半胱胺对HPA轴的激活可能与其致溃疡作用有关。
Hypothalamic CRF and plasma corticosterone levels were significantly increased after cysteamine injection, indicating that cysteamine activated the hypothalamic-pituitary-adrenal cortex (HPA) system. Rats in experimental group were given adrenocortical atrophy by dexamethasone 4 consecutive days before injection, cysteamine was given on the 5th and 12th day after stopping the treatment, respectively, and the induced ulcers were more obvious than the control animals without dexamethasone preconditioning Reduce their ulcer index were 20% and 19% of the control group (P <0.01). The results suggest that activation of cysteamine on the HPA axis may be related to its role in causing ulcers.